Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physiological objectives and you can pharmacology out-of curcumin

Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‚s the big part of the fresh red dye away from turmeric, an Indian spruce that is extracted from the fresh new rhizome of your exotic bush Curcuma longa, and therefore is one of the Zingiberaceae loved ones. Within section, i talk about the pharmacological situations away from curcumin and you may speak about the fresh molecular angles of these circumstances. We upcoming feedback the fresh new demonstrated and you can prospective medical spends off curcumin. Curcumin is known historically because the a healing agent, but its apparatus of action try detailed. The fresh pharmacological effects of curcumin seem to be the consequence of an excellent synergism off communities from weakened biochemical relationships having several physiological purpose in the interconnected signaling routes. These types of aim are nutrients such as for instance cyclooxygenase, lipoxygenase and you will necessary protein kinases, and you may transcription products instance NF-?B, STAT and Nrf2. Modulation of those particles affects downstream affectors that produce the newest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial activities away from curcumin. This type of outcomes had been looked at from inside the logical samples from curcumin to own problems and you will inflammatory ailment, cancers, Alzheimer condition, aerobic disorder, and you may all forms of diabetes. This new trials purchased variable dosages out-of curcuminwith various other frequencies and you can course, on general conclusion you to definitely high amounts out-of curcumin at quantity of g have to obtain healing effects. Read more

Curcumin: Synthesis, Emerging Role inside Serious pain Management and you will Wellness Effects

Book Part Examples of plant-derived pharmaceuticals having become the attention from persisted and you may exponential lookup and you can innovation attention have, yet, been a little scarce. Immediately following several years, the last 2 decades have been described as a good 100-fold escalation in the number of scientific blogs penned per year one to try of benefit towards the access to curcumin for the biomedicine. Find out more

Structure, synthesis and physiological items out of curcumin prodrugs

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many possible pharmacological effects and may have therapeutic software in many problem claims, as discussed in more detail in the last chapter. not, the potential logical effectiveness off curcumin is bound from the their physicochemical features off bad water solubility and you can imbalance, which produce lower bioavailability. Prodrugs of curcumin bring ways to upgrade of your biopharmaceutical and you may pharmacokinetic features, and may ensure it is exploitation https://lovingwomen.org/da/varme-og-sexede-tyske-kvinder/ of the pharmacological results of curcumin. Contained in this section, we first comment the physicochemical and you will pharmacokinetics out-of curcumin. I following establish the design of curcumin prodrugs which have enhanced drinking water solubility and you will improved chemical compounds balances that is certainly translated back to totally free curcumin up on bioactivation into the vivo. We emphasize present achievement of this type, with a focus on the construction, synthesis and you will testing off prodrugs centered on promoieties as well as amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric information like hyaluronic acidic and you can polyethylene glycol. So it part has got the basis for optimisation of your own physicochemical and you may biopharmaceutical qualities in addition to biological affairs out-of curcumin prodrugs, on objective having fun with of those curcumin derivatives inside the systematic programs. Read more